Hi! Alexander,   
      
   On 04/23/2016 05:25 PM, you wrote:   
      
    ak>>> "What happened to/with you?"   
    ak>>> I saw both variants in books. Is there any difference?   
      
    ak> For instance, in "An Inspector Calls", by J.B. Prestley:   
    ak> -------------------------   
    ak> INSPECTOR: What's the matter with him?   
      
   To a native speaker this is a different question entirely.  (I inserted the   
   "the" there as it seemed to be missing from your quote, BTW.)  In this case,   
   'with' is the only correct choice.  'To' just doesn't work.   
      
   Alternatively, the Inspector may have asked "What happened with him?", or,   
   "What happened to him?".  Either of which would have been correct.   
      
   Cheers,   
   Paul.   
      
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