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   Message 8,856 of 8,931   
   ScienceDaily to All   
   A neurobehavioral signature of risk for    
   11 Jul 23 22:30:30   
   
   MSGID: 1:317/3 64ae2c77   
   PID: hpt/lnx 1.9.0-cur 2019-01-08   
   TID: hpt/lnx 1.9.0-cur 2019-01-08   
    A neurobehavioral signature of risk for mania    
      
     Date:   
         July 11, 2023   
     Source:   
         Elsevier   
     Summary:   
         Mania, in which mood and energy level are extremely elevated for   
         at least a week, and hypomania, which is less severe and lasts at   
         least four days, are the defining features of bipolar spectrum   
         disorders (BSD) and can be the most disruptive symptoms. A new   
         study now identifies a signature of risk for developing future   
         mania or hypomania.   
      
      
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   ==========================================================================   
   FULL STORY   
   ==========================================================================   
   Mania, in which mood and energy level are extremely elevated for at least   
   a week, and hypomania, which is less severe and lasts at least four days,   
   are the defining features of bipolar spectrum disorders (BSD) and can   
   be the most disruptive symptoms. A new study in Biological Psychiatry:   
   Cognitive Neuroscience and Neuroimaging, published by Elsevier, now   
   identifies a signature of risk for developing future mania or hypomania.   
      
   BSD are psychiatric conditions that typically emerge in young adulthood,   
   often severely disrupting lives and requiring intensive treatments. Mania   
   risk has remained challenging for clinicians to predict; the ability to   
   do so would aid in directing treatments to at-risk patients sooner.   
      
   The researchers, led by Adriane M. Soehner, PhD, at the University of   
   Pittsburgh, built on previous research showing that heightened reward   
   motivation and sleep-circadian rhythm disruption are associated with   
   mania/ hypomania onset. Brain imaging studies have also shown that BSD   
   is associated with elevated reward expectancy activation in the left   
   ventrolateral prefrontal cortex, a key reward- and salience-processing   
   hub.   
      
   For the current study, Dr. Soehner and colleagues clustered these   
   markers together; they hypothesized that a signature of increased mania   
   risk would be marked by elevated reward sensitivity, impulsivity, and   
   sleep-circadian characteristics. Young adult participants, who did not   
   have a diagnosis of BSD, completed assessments and underwent functional   
   magnetic resonance imaging.   
      
   About half the participants also underwent follow-up assessments at six   
   and 12 months.   
      
   Three "profiles" emerged from the sample: one healthy, one at moderate   
   risk, and one at high risk. Individuals at high risk had elevated mania   
   symptoms at baseline compared to the other two groups. Over the 12-month   
   follow-up interval, mania symptoms in both the high-risk and moderate-risk   
   groups exceeded the healthy group.   
      
   Dr. Soehner said of the findings, "Here, we identified neurobehavioral   
   profiles based on reward sensitivity, impulsivity, and sleep-circadian   
   characteristics that help distinguish those with elevated mania   
   vulnerability. These characteristics, in combination, may help   
   detect mania risk and provide targets to guide and monitor early   
   interventions."  Cameron Carter, MD, Editor of Biological Psychiatry:   
   Cognitive Neuroscience and Neuroimaging, said of the work, "New findings   
   such as these highlight our emerging ability to combine neurobiological   
   and clinical measures to identify groups of patients at highest risk   
   for serious mental health problems such as mania, allowing for early   
   identification and intervention for those at highest risk. Future   
   research is needed to show that this can lead to reduced suffering and   
   better outcomes in individuals identified in this way."   
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                   # Sleep_Disorder_Research # Asthma #   
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                   # Bipolar_Disorder # Sleep_Disorders # Mental_Health   
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             o Bipolar_disorder o Mental_illness o PMS o Measles   
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   provided by Elsevier. Note: Content may be edited for style and length.   
      
      
   ==========================================================================   
   Journal Reference:   
      1. Adriane M. Soehner, Meredith L. Wallace, Kale Edmiston, Henry   
      W. Chase,   
         Jeannette Lockovich, Haris Aslam, Richelle Stiffler, Simona Graur,   
         Alex Skeba, Genna Bebko, Osasumwen E. Benjamin, Yiming Wang,   
         Mary L. Phillips.   
      
         Neurobehavioral Reward and Sleep-Circadian Profiles Predict   
         Present and Next-Year Mania/Hypomania Symptoms. Biological   
         Psychiatry: Cognitive Neuroscience and Neuroimaging, 2023; DOI:   
         10.1016/j.bpsc.2023.04.012   
   ==========================================================================   
      
   Link to news story:   
   https://www.sciencedaily.com/releases/2023/07/230711133131.htm   
      
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