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|    A neurobehavioral signature of risk for     |
|    11 Jul 23 22:30:30    |
      MSGID: 1:317/3 64ae2c77       PID: hpt/lnx 1.9.0-cur 2019-01-08       TID: hpt/lnx 1.9.0-cur 2019-01-08        A neurobehavioral signature of risk for mania                Date:        July 11, 2023        Source:        Elsevier        Summary:        Mania, in which mood and energy level are extremely elevated for        at least a week, and hypomania, which is less severe and lasts at        least four days, are the defining features of bipolar spectrum        disorders (BSD) and can be the most disruptive symptoms. A new        study now identifies a signature of risk for developing future        mania or hypomania.                      Facebook Twitter Pinterest LinkedIN Email              ==========================================================================       FULL STORY       ==========================================================================       Mania, in which mood and energy level are extremely elevated for at least       a week, and hypomania, which is less severe and lasts at least four days,       are the defining features of bipolar spectrum disorders (BSD) and can       be the most disruptive symptoms. A new study in Biological Psychiatry:       Cognitive Neuroscience and Neuroimaging, published by Elsevier, now       identifies a signature of risk for developing future mania or hypomania.              BSD are psychiatric conditions that typically emerge in young adulthood,       often severely disrupting lives and requiring intensive treatments. Mania       risk has remained challenging for clinicians to predict; the ability to       do so would aid in directing treatments to at-risk patients sooner.              The researchers, led by Adriane M. Soehner, PhD, at the University of       Pittsburgh, built on previous research showing that heightened reward       motivation and sleep-circadian rhythm disruption are associated with       mania/ hypomania onset. Brain imaging studies have also shown that BSD       is associated with elevated reward expectancy activation in the left       ventrolateral prefrontal cortex, a key reward- and salience-processing       hub.              For the current study, Dr. Soehner and colleagues clustered these       markers together; they hypothesized that a signature of increased mania       risk would be marked by elevated reward sensitivity, impulsivity, and       sleep-circadian characteristics. Young adult participants, who did not       have a diagnosis of BSD, completed assessments and underwent functional       magnetic resonance imaging.              About half the participants also underwent follow-up assessments at six       and 12 months.              Three "profiles" emerged from the sample: one healthy, one at moderate       risk, and one at high risk. Individuals at high risk had elevated mania       symptoms at baseline compared to the other two groups. Over the 12-month       follow-up interval, mania symptoms in both the high-risk and moderate-risk       groups exceeded the healthy group.              Dr. Soehner said of the findings, "Here, we identified neurobehavioral       profiles based on reward sensitivity, impulsivity, and sleep-circadian       characteristics that help distinguish those with elevated mania       vulnerability. These characteristics, in combination, may help       detect mania risk and provide targets to guide and monitor early       interventions." Cameron Carter, MD, Editor of Biological Psychiatry:       Cognitive Neuroscience and Neuroimaging, said of the work, "New findings       such as these highlight our emerging ability to combine neurobiological       and clinical measures to identify groups of patients at highest risk       for serious mental health problems such as mania, allowing for early       identification and intervention for those at highest risk. Future       research is needed to show that this can lead to reduced suffering and       better outcomes in individuals identified in this way."        * RELATED_TOPICS        o Health_&_Medicine        # Sleep_Disorder_Research # Asthma #        Mental_Health_Research # Multiple_Sclerosis_Research        o Mind_&_Brain        # Bipolar_Disorder # Sleep_Disorders # Mental_Health        # Behavior        * RELATED_TERMS        o Bipolar_disorder o Mental_illness o PMS o Measles        o Controversy_about_ADHD o Clinical_depression o        Salmonella_infection o Pregnancy              ==========================================================================               Print               Email               Share       ==========================================================================       ****** 1 ****** ***** 2 ***** **** 3 ****       *** 4 *** ** 5 ** Breaking this hour       ==========================================================================        * Revolutionary_Electric_Artificial_Muscles *        Age_of_Universe:_26.7,_Not_13.7,_Billion_Years *        City_Ground_Is_Deforming:_Buildings_Aren't_Ready        * The_Sound_of_Silence?_People_Hear_It *        36-Million-Year_Geological_Cycle_Drives_...               * Six_Foods_to_Boost_Cardiovascular_Health        * Cystic_Fibrosis:_Lasting_Improvement *        Artificial_Cells_Demonstrate_That_'Life_...               * Advice_to_Limit_High-Fat_Dairy_Foods_Challenged *        First_Snapshots_of_Fermion_Pairs              Trending Topics this week       ==========================================================================       HEALTH_&_MEDICINE Cholesterol Mental_Health_Research Brain_Tumor       MIND_&_BRAIN Intelligence Brain_Injury Educational_Psychology       LIVING_&_WELL Healthy_Aging Nutrition Child_Development                     ==========================================================================              Strange & Offbeat       ==========================================================================       HEALTH_&_MEDICINE Revolutionary_Self-Sensing_Electric_Artificial_Muscles       These_Lollipops_Could_'Sweeten'_Diagnostic_Testing_for_Kids_and_Adults_Alike       Holograms_for_Life:_Improving_IVF_Success MIND_&_BRAIN       The_Sound_of_Silence?_Researchers_Demonstrate_People_Hear_It       AI_Tests_Into_Top_1%_for_Original_Creative_Thinking       Everyone's_Brain_Has_a_Pain_Fingerprint_--_New_Research_Has_Revealed_for_the       First_Time LIVING_&_WELL       Grocery_Store_Carts_Set_to_Help_Diagnose_Common_Heart_Rhythm_Disorder_and       Prevent_Stroke Illusions_Are_in_the_Eye,_Not_the_Mind       Amputees_Feel_Warmth_in_Their_Missing_Hand Story Source: Materials       provided by Elsevier. Note: Content may be edited for style and length.                     ==========================================================================       Journal Reference:        1. Adriane M. Soehner, Meredith L. Wallace, Kale Edmiston, Henry        W. Chase,        Jeannette Lockovich, Haris Aslam, Richelle Stiffler, Simona Graur,        Alex Skeba, Genna Bebko, Osasumwen E. Benjamin, Yiming Wang,        Mary L. Phillips.               Neurobehavioral Reward and Sleep-Circadian Profiles Predict        Present and Next-Year Mania/Hypomania Symptoms. Biological        Psychiatry: Cognitive Neuroscience and Neuroimaging, 2023; DOI:        10.1016/j.bpsc.2023.04.012       ==========================================================================              Link to news story:       https://www.sciencedaily.com/releases/2023/07/230711133131.htm              --- up 1 year, 19 weeks, 1 day, 10 hours, 50 minutes        * Origin: -=> Castle Rock BBS <=- Now Husky HPT Powered! 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