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   TID: hpt/lnx 1.9.0-cur 2019-01-08   
    Fluctuating levels of cholesterol and triglycerides linked to increased   
   risk of dementia    
      
     Date:   
         July 5, 2023   
     Source:   
         American Academy of Neurology   
     Summary:   
         Older people who have fluctuating levels of cholesterol and   
         triglycerides may have a higher risk of Alzheimer's disease and   
         related dementias compared to people who have steady levels,   
         according to new research.   
      
         While the study found a link, it does not prove that fluctuating   
         levels of cholesterol and triglycerides cause dementia.   
      
      
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   Older people who have fluctuating levels of cholesterol and triglycerides   
   may have a higher risk of Alzheimer's disease and related dementias   
   compared to people who have steady levels, according to new research   
   published in the July 5, 2023, online issue of Neurology(R), the medical   
   journal of the American Academy of Neurology. While the study found   
   a link, it does not prove that fluctuating levels of cholesterol and   
   triglycerides cause dementia.   
      
   "Prevention strategies for Alzheimer's and related dementias are   
   urgently needed," said study author Suzette J. Bielinski, PhD, of the   
   Mayo Clinic in Rochester, Minnesota. "Routine screenings for cholesterol   
   and triglyceride levels are commonly done as part of standard medical   
   care. Fluctuations in these results over time could potentially help   
   us identify who is at greater risk for dementia, help us understand   
   mechanisms for the development of dementia and ultimately determine   
   whether leveling out these fluctuations could play a role in reducing   
   dementia risk."  Researchers used health care data to identify 11,571   
   people age 60 or older who did not have a prior diagnosis of Alzheimer's   
   disease or dementia. Researchers looked at participants' measurements of   
   total cholesterol, triglycerides, low- density lipoprotein cholesterol   
   (LDL) and high-density lipoprotein cholesterol (HDL) on at least three   
   different days in the five years before the start of the study.   
      
   Then researchers divided participants into five equal groups based on   
   how much the measurements fluctuated. The lowest group had the least   
   variation over time and the highest group had the most variation.   
      
   Participants were followed for an average of 13 years. During that time,   
   2,473 people developed Alzheimer's disease or another form of dementia.   
      
   After adjusting for variables that could affect risk of dementia including   
   sex, race, education and lipid-lowering treatments, researchers found   
   for total cholesterol, participants in the highest group had a 19%   
   increased risk of dementia compared to those in the lowest group. Of the   
   2,311 people in the highest group, 515 developed dementia compared to   
   483 of the 2,311 people in the lowest group. For triglycerides, those   
   in highest group had a 23% increased risk.   
      
   Researchers did not find a link between variations in LDL and HDL and   
   an increased risk of dementia.   
      
   "It remains unclear why and how fluctuating levels of cholesterol   
   and triglycerides are related to the risk of Alzheimer's disease,"   
   said Bielinski.   
      
   "Further studies looking at the changes over time for this relationship   
   are needed in order to confirm our results and potentially consider   
   preventative strategies."  A limitation of the study was researchers   
   looked at Alzheimer's disease and related dementias as a whole and did   
   not differentiate between the types of dementia.   
      
   The study was supported by the National Heart, Lung and Blood Institute.   
      
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   Worthy_of_a_Toast Story Source: Materials provided by   
   American_Academy_of_Neurology. Note: Content may be edited for style   
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   Journal Reference:   
      1. Ethan D. Moser, Sheila M. Manemann, Nicholas B. Larson, Jennifer   
      L. St.   
      
         Sauver, Paul Y. Takahashi, Michelle M. Mielke, Walter A. Rocca,   
         Janet E.   
      
         Olson, Ve'ronique L. Roger, Alan T. Remaley, Paul A. Decker, Jill M.   
      
         Killian, Suzette J. Bielinski. Association Between Fluctuations   
         in Blood Lipid Levels Over Time With Incident Alzheimer Disease   
         and Alzheimer Disease Related Dementias. Neurology, 2023; DOI:   
         10.1212/ WNL.0000000000207595   
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   Link to news story:   
   https://www.sciencedaily.com/releases/2023/07/230705171104.htm   
      
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