MSGID: 1:317/3 64a64363   
   PID: hpt/lnx 1.9.0-cur 2019-01-08   
   TID: hpt/lnx 1.9.0-cur 2019-01-08   
    Holograms for life: Improving IVF success    
      
     Date:   
         July 5, 2023   
     Source:   
         University of Adelaide   
     Summary:   
         In a world-first, 3D holographic images of an embryo have been   
         developed.   
      
         The images are created using minuscule amounts of light in a   
         fraction of a second.   
      
      
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   In a world-first, 3D holographic images of an embryo have been developed   
   as part of a collaborative research project between the University of   
   Adelaide and University of St Andrews. The images are created using   
   miniscule amounts of light in a fraction of a second.   
      
   The team, led by Dr Kylie Dunning, Hospital Research Foundation   
   fellow from the University of Adelaide's Robinson Research Institute,   
   and Professor Kishan Dholakia from the University of Adelaide and the   
   University of St Andrews, developed an approach to create 3D holographic   
   images of the pre-clinical model of an embryo at various stages of   
   development.   
      
   "For couples wishing to conceive, the quality, or developmental potential,   
   of an embryo is critical as it dictates the success of their pregnancy   
   and ultimately, the birth of their child," said Dr Dunning.   
      
   "In vitro fertilisation (IVF) clinics routinely assess embryo   
   quality by visual inspection to check if an embryo is developing in   
   a time-appropriate manner or by an invasive biopsy to determine DNA   
   content of the biopsied sample.   
      
   "However, these approaches have failed to improve the success rate of   
   IVF which has remained stagnant for more than a decade."  A non-invasive   
   approach without biopsy to help pick the most appropriate embryo is   
   a highly beneficial tool for the 21st century embryologist: light can   
   fulfill this need.   
      
   3D holographic images are a non-invasive approach which provides insights   
   into the embryo by identifying detailed features. This may augment   
   conventional visual assessment for embryo quality in an IVF clinic,   
   allowing an embryologist to make an informed decision on the selection   
   of best quality embryos.   
      
   "Optical technologies hold immense promise to unravel the metabolism and   
   health of the embryo. This gentle, non-invasive approach could lead to   
   improved IVF success," said Dr Dunning.   
      
   Data from 2020 show that the success rates of IVF range from a live birth   
   rate of 38.9 per cent per embryo transfer for patients under 34 years,   
   to a live birth rate of 5.6 per cent per embryo transfer for patients   
   over 43 years. In 2018 it was estimated that eight million babies had   
   been born through IVF since the world's first in 1978.   
      
   "This technology uses minuscule amounts of light -- less than that   
   from your smartphone -- to allow rapid visualisation of the embryo in   
   a fraction of a second," said Professor Dholakia.   
      
   "It's a prime example of interdisciplinary success for our new Centre   
   of Light for Life at the University of Adelaide, and of collaborative   
   international work with my group at the University of St Andrews,   
   Scotland."  The team aims to have the technology, which is being developed   
   through research using a preclinical model, available in five years.   
      
   This cutting-edge development would not have been possible without the   
   support of funding from the UK and EU, and the Australian Research Council   
   (ARC), National Health and Medical Research Council and the Hospital   
   Research Foundation in Australia.   
      
   Primary authors on the study are George Dwapanyin, postdoctoral researcher   
   at the University of St Andrews and Darren Chow, PhD candidate at   
   the Robinson Research Institute, School of Biomedicine, University   
   of Adelaide.   
      
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   Journal Reference:   
      1. George O. Dwapanyin, Darren J. X. Chow, Tiffany C. Y. Tan,   
      Nicolas S.   
      
         Dubost, Josephine M. Morizet, Kylie R. Dunning, Kishan Dholakia.   
      
         Investigation of refractive index dynamics during in   
         vitro embryo development using off-axis digital holographic   
         microscopy. Biomedical Optics Express, 2023; 14 (7): 3327 DOI:   
         10.1364/BOE.492292   
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   Link to news story:   
   https://www.sciencedaily.com/releases/2023/07/230705194525.htm   
      
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