MSGID: 1:317/3 649a65e9   
   PID: hpt/lnx 1.9.0-cur 2019-01-08   
   TID: hpt/lnx 1.9.0-cur 2019-01-08   
    Lean body mass, age linked with alcohol elimination rates in women   
      
      
     Date:   
         June 26, 2023   
     Source:   
         University of Illinois at Urbana-Champaign, News Bureau   
     Summary:   
         Research links women's lean body mass with how quickly they   
         eliminate alcohol from their system. Women with obesity and those   
         who are older eliminate alcohol from their bloodstreams faster   
         than those of normal weight and those who are younger.   
      
      
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   FULL STORY   
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   The rate at which women eliminate alcohol from their bloodstream is   
   largely predicted by their lean body mass, although age plays a role,   
   too, scientists found in a new study. Women with obesity -- and those   
   who are older -- clear alcohol from their systems 52% faster than women   
   of healthy weights and those who are younger, the study found.   
      
   Lean body mass is defined in the study -- published in the journal   
   Alcohol Clinical and Experimental Research -- as one's total body weight   
   minus fat.   
      
   "We believe the strong relationship we found between participants' lean   
   body mass and their alcohol elimination rate is due to the association   
   that exists between lean body mass and lean liver tissue -- the part   
   of the liver responsible for metabolizing alcohol," said research group   
   leader M. Yanina Pepino, a professor of food science and human nutrition   
   at the University of Illinois Urbana-Champaign.   
      
   To explore links between body composition and alcohol elimination rates,   
   the team conducted a secondary analysis of data from a study performed   
   at the U. of I and another at Indiana University, Indianapolis. Both   
   projects used similar methods to estimate the rate at which alcohol is   
   broken down in the body.   
      
   The combined sample from the studies used in the analysis included 143   
   women who ranged in age from 21 to 64 and represented a wide range of   
   body mass indices -- from healthy weights to severe obesity. Among these   
   were 19 women who had undergone different types of bariatric surgery.   
      
   In a subsample of 102 of these women, the researchers had measured   
   the proportions of lean and fat tissue in their bodies and calculated   
   their body mass indices. Based on their BMI, those in the subsample were   
   divided into three groups: normal weight, which included women with BMI   
   ranging from 18.5- 24.9; overweight, those with BMI ranging from 25-29.9;   
   and obese, participants with BMI above 30.   
      
   As the researchers expected, women with higher BMI had not only more   
   fat mass than women of healthy weights, they also had more lean mass. On   
   average, the group with obesity had 52.3 kg of lean mass, compared with   
   47.5 kg for the normal weight group.   
      
   The two studies both used an alcohol clamp technique, where participants   
   received an intravenous infusion of alcohol at a rate controlled by a   
   computer- assisted system. The system calculated personalized infusion   
   rates based upon each participant's age, height, weight and gender and   
   was programmed so they would reach a target blood alcohol concentration   
   of .06 percent within 15 minutes and maintain that level for about two   
   hours Using a breathalyzer, breath samples were collected at regular   
   intervals throughout the experiments to estimate participants' blood   
   alcohol concentration and provide feedback to the system.   
      
   "We found that having a higher fat-free body mass was associated   
   with a faster alcohol elimination rate, particularly in women in the   
   oldest subgroups," said Neda Seyedsadjadi, a postdoctoral fellow at the   
   university and the first author of the study.   
      
   "The average alcohol elimination rates were 6 grams per hour for the   
   healthy weight group, 7 grams for the overweight group, and 9 grams   
   for the group with obesity," she said. "To put this in perspective, one   
   standard drink is 14 grams of pure alcohol, which is found in 12 ounces   
   of beer, 5 ounces of table wine or 1.5 ounces shot of distilled spirits."   
   The interaction between participants' age and lean body mass accounted   
   for 72% of the variance in the time required to eliminate the alcohol   
   from their system, the team found.   
      
   Pepino, who also holds an appointment as a health innovation professor   
   at Carle Illinois College of Medicine, has conducted several studies on   
   alcohol response in bariatric surgery patients.   
      
   The findings also shed light on alcohol metabolism and body composition   
   in women who have undergone weight loss surgery. Researchers have long   
   known that bariatric surgery alters women's response to alcohol but   
   were uncertain if it affected how quickly they cleared alcohol from   
   their systems.   
      
   Some prior studies found that these patients metabolized alcohol more   
   slowly after they had weight loss surgery. The new study's findings   
   indicate that these participants' slower alcohol elimination rates can be   
   explained by surgery-induced reductions in their lean body mass. Weight   
   loss surgery itself had no independent effects on patients' alcohol   
   elimination rates, the team found.   
      
   Additional co-authors of the current study were Dr. Blair Rowitz,   
   associate dean for clinical affairs with the Carle Illinois College of   
   Medicine; Vijay A.   
      
   Ramchandani, a senior investigator in the section on human   
   psychopharmocology at the National Institute on Alcohol Abuse and   
   Alcoholism; and psychiatry professors Dr. Martin H. Plawecki and Dr. Sean   
   J. O'Connor, and scientist in neurology Ann E.K. Kosobud, all of the   
   Indiana University School of Medicine.   
      
       * RELATED_TOPICS   
             o Health_&_Medicine   
                   # Obesity # Diet_and_Weight_Loss # Fitness # Triglycerides   
             o Mind_&_Brain   
                   # Alcoholism # Addiction # Dieting_and_Weight_Control #   
                   Gender_Difference   
       * RELATED_TERMS   
             o Methanol o Hair o Blood_alcohol_content o Alcoholism o   
             Obesity o Fetal_alcohol_spectrum_disorder o Overweight o Dioxin   
      
   ==========================================================================   
   Story Source: Materials provided by   
   University_of_Illinois_at_Urbana-Champaign,_News_Bureau.   
      
   Original written by Sharita Forrest. Note: Content may be edited for   
   style and length.   
      
      
   ==========================================================================   
   Journal Reference:   
      1. Neda Seyedsadjadi, Vijay A. Ramchandani, Martin H. Plawecki,   
      Ann E. K.   
      
         Kosobud, Sean O'Connor, Blair Rowitz, Marta Yanina   
         Pepino. Fat‐free mass accounts for most of the variance   
         in alcohol elimination rate in women. Alcohol: Clinical and   
         Experimental Research, 2023; 47 (5): 848 DOI: 10.1111/acer.15047   
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   Link to news story:   
   https://www.sciencedaily.com/releases/2023/06/230626164151.htm   
      
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