MSGID: 1:317/3 64927d1c   
   PID: hpt/lnx 1.9.0-cur 2019-01-08   
   TID: hpt/lnx 1.9.0-cur 2019-01-08   
    Low-dose aspirin may increase anaemia risk in healthy older adults:   
   study    
      
     Date:   
         June 20, 2023   
     Source:   
         Monash University   
     Summary:   
         A new study analysing data from the landmark ASPREE trial has found   
         that prolonged daily aspirin use increases the risk of anaemia   
         by 20 per cent in people mostly aged 70 and over. The results   
         have prompted researchers to suggest that regular monitoring for   
         anaemia be considered for older adults who take low-dose aspirin,   
         and if older adults have concerns about their health or medications   
         they should discuss them with their GP.   
      
      
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   FULL STORY   
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   A new study analysing data from the landmark ASPREE trial has found that   
   prolonged daily aspirin use increases the risk of anaemia by 20 per cent   
   in people mostly aged 70 and over.   
      
   The results have prompted researchers to suggest that regular monitoring   
   for anaemia be considered for older adults who take low-dose aspirin,   
   and if older adults have concerns about their health or medications they   
   should discuss them with their GP.   
      
   The results have prompted researchers to suggest that regular monitoring   
   for anaemia be considered for older adults who take low-dose aspirin and   
   to discuss any concerns about their health or medications with their GP.   
      
   The Monash University-led study, published in Annals of Internal Medicine,   
   followed 18,153 initially healthy older adults in Australia and the USA   
   and recorded incidents of anaemia over an average 4.7 years.   
      
   The risk of developing anaemia was found to be 20 per cent higher in   
   the aspirin group compared to those in the placebo group.   
      
   It was the largest study to investigate anaemia in older people as part   
   of a randomised controlled trial, ASPREE (ASPirin in Reducing Events   
   in the Elderly) -- with half the participants taking a placebo and the   
   other half a daily low dose (100mg) of aspirin.   
      
   Anaemia is commonly experienced by older adults, potentially affecting   
   overall function and increasing fatigue, disabilities, depressive symptoms   
   and cognitive problems.   
      
   In addition to a higher risk of anaemia, blood tests revealed a faster   
   decline of haemoglobin and reduced ferritin (a protein that carries iron)   
   levels in the aspirin group compared to the placebo group.   
      
   Lead author, Associate Professor Zoe McQuilten from Monash University's   
   School of Public Health and Preventive Medicine, said while bleeding   
   was a known side- effect of aspirin, few previous studies had looked at   
   the effect of prolonged aspirin use on the progressive development of   
   anaemia in older adults.   
      
   "This study gives a clearer picture of the additional risk of becoming   
   anaemic with aspirin use and the impact is likely to be greater in older   
   adults with underlying diseases, such as kidney disease," Associate   
   Professor McQuilten said.   
      
   Associate Professor McQuilten said the new data gave doctors insight   
   into the risk of anaemia from prolonged aspirin use by their older   
   patients. "Older adults are more likely to become anaemic generally   
   and now doctors can potentially identify patients at higher risk of   
   developing anaemia," she said.   
      
   Associate Professor McQuilten urged patients to follow the advice of   
   their doctor about their daily use of aspirin. She cautioned that for   
   some older adults, aspirin was recommended as a valuable therapy to   
   prevent recurring heart attacks or stroke. "Patients should not change   
   their aspirin regimen without speaking to their GP," she said.   
      
       * RELATED_TOPICS   
             o Health_&_Medicine   
                   # Elder_Care # Anemia # Mental_Health_Research #   
                   Stroke_Prevention # Menopause # Sickle_Cell_Anemia #   
                   Diseases_and_Conditions # Today's_Healthcare   
       * RELATED_TERMS   
             o Hair o Mammography o Trans_fat o Aspirin o Alzheimer's_disease   
             o Adult_attention-deficit_disorder o Zone_diet o   
             General_fitness_training   
      
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   Story Source: Materials provided by Monash_University. Note: Content   
   may be edited for style and length.   
      
      
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   Journal Reference:   
      1. Zoe K. McQuilten, Le Thi Phuong Thao, Sant-Rayn Pasricha, Andrew   
      S. Artz,   
         Michael Bailey, Andrew T. Chan, Harvey Jay Cohen, Jessica   
         E. Lockery, Anne M. Murray, Mark R. Nelson, Hans G. Schneider,   
         Rory Wolfe, Robyn L.   
      
         Woods, Erica M. Wood, John J. McNeil. Effect of Low-Dose Aspirin   
         Versus Placebo on Incidence of Anemia in the Elderly. Annals of   
         Internal Medicine, 2023; DOI: 10.7326/M23-0675   
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   Link to news story:   
   https://www.sciencedaily.com/releases/2023/06/230620113801.htm   
      
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