MSGID: 1:317/3 6482aafa   
   PID: hpt/lnx 1.9.0-cur 2019-01-08   
   TID: hpt/lnx 1.9.0-cur 2019-01-08   
    The IL-17 protein plays a key role in skin aging    
      
     Date:   
         June 8, 2023   
     Source:   
         Institute for Research in Biomedicine (IRB Barcelona)   
     Summary:   
         A team of scientists has discovered that IL-17 protein plays a   
         central role in skin aging. The study highlights an IL-17-mediated   
         ageing process to an inflammatory state.   
      
      
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   FULL STORY   
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   A team of scientists from the Institute for Research in Biomedicine   
   (IRB Barcelona) in collaboration with the National Center for Genomic   
   Analysis (CNAG) has discovered that IL-17 protein plays a central role   
   in skin ageing.   
      
   The study, which was led by Dr. Guiomar Solanas, Dr. Salvador Aznar   
   Benitah, both at IRB Barcelona, and Dr. Holger Heyn, at CNAG, highlights   
   an IL-17- mediated ageing process to an inflammatory state.   
      
   Skin ageing is characterised by a series of structural and functional   
   changes that gradually contribute to the deterioration and fragility   
   associated with age. Aged skin has a reduced capacity to regenerate,   
   poor healing ability, and diminished barrier function.   
      
   Published in the journalNature Aging, this work describes the changes   
   undergone by different types of cells with ageing and identifies how   
   some immune cells in the skin express high levels of IL-17.   
      
   "Our results show that IL-17 is involved in various functions related   
   to ageing. We have observed that blocking the function of this protein   
   slows down the appearance of various deficiencies associated with ageing   
   skin. This discovery opens up new possibilities for treating some of   
   the symptoms or facilitating skin recovery after surgery, for example,"   
   explains Dr. Aznar Benitah, ICREA researcher and head of the Stem Cells   
   and Cancer laboratory at IRB Barcelona.   
      
   "Single cell sequencing has allowed us to dive deep into the complexity   
   of cell types and states forming the skin and how these change during   
   lifespan. We did not only find differences in the composition of aged   
   skin, but also changes in cell activity states. Particularly immune   
   cells showed specific age-related profiles, which we could pinpoint by   
   analyzing thousands of individual cells on at a time," says Dr. Holger   
   Heyn, head of the Single Cell Genomics laboratory at CNAG.   
      
   Immune cells, inflammation, and ageing In addition to a wide variety of   
   epithelial cells, hair follicle cells, and other components, the skin   
   is also home to immune cells, which play a crucial role in preventing   
   infection and protecting against different damages.   
      
   The study describes how, during ageing, the presence of some of these   
   immune cells, namely gamma delta T cells, innate lymphoid cells, and   
   CD4+ T cells, significantly increases in the skin. These same cells also   
   start expressing very high levels of the pro-inflammatory cytokine IL-17.   
      
   "Ageing is associated with mild but persistent inflammation and, in the   
   skin, this is characterised by a significant increase in IL-17, which   
   causes skin deterioration," explains Dr. Paloma Sola', first author of   
   the paper, together with Dr. Elisabetta Mereu, who is now a researcher   
   at the Josep Carreras Leukemia Research Institute.   
      
   Reversing the symptoms of ageing in skin Previous studies had described   
   that IL-17 is related to some autoimmune skin diseases, such as psoriasis,   
   and there are existing treatments that block this protein. The team of   
   researchers studied the response of various aspects to blocking IL-17   
   activity, including hair follicle growth, transepidermal water loss, wound   
   healing, and genetic markers of ageing. These four parameters showed an   
   improvement after treatment, as the acquisition of these ageing traits   
   was significantly delayed.   
      
   "IL-17 protein is essential for vital body functions, such as defense   
   against microbes and wound healing, so permanently blocking it would   
   not be an option.   
      
   What we have observed is that its temporary inhibition offers benefits   
   that could be of interest at a therapeutic level," saysDr. Guiomar   
   Solanas, associate researcher at IRB Barcelona.   
      
   Future work by the researchers will focus on clarifying the ageing   
   processes that are related to inflammatory states in the skin and how   
   these are linked to IL-17. The team will also address whether IL-17 is   
   involved in the ageing and deterioration of other tissues and organs.   
      
   This research has received funding from the European Research Council   
   (ERC), the Government of Catalonia, the Spanish Ministry of Science and   
   Innovation, the Lilliane Bettencourt Foundation, the State Research Agency   
   (AEI), and the European Regional Development Fund (ERDF).   
      
       * RELATED_TOPICS   
             o Health_&_Medicine   
                   # Skin_Care # Immune_System # Skin_Cancer # Psoriasis #   
                   Healthy_Aging # Stem_Cells # Lymphoma # Cosmetics   
       * RELATED_TERMS   
             o Collagen o Acne o Molecular_biology o Psoriasis o Cholesterol   
             o Liver o Epinephrine o Ultraviolet   
      
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   Story Source: Materials provided by   
   Institute_for_Research_in_Biomedicine_(IRB_Barcelona).   
      
   Note: Content may be edited for style and length.   
      
      
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   Journal Reference:   
      1. Paloma Sola', Elisabetta Mereu, Ju'lia Bonjoch, Marta   
      Casado-Pela'ez,   
         Neus Prats, Mo`nica Aguilera, Oscar Reina, Enrique Blanco, Manel   
         Esteller, Luciano Di Croce, Holger Heyn, Guiomar Solanas, Salvador   
         Aznar Benitah. Targeting lymphoid-derived IL-17 signaling to delay   
         skin aging.   
      
         Nature Aging, 2023; DOI: 10.1038/s43587-023-00431-z   
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   Link to news story:   
   https://www.sciencedaily.com/releases/2023/06/230608121031.htm   
      
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