MSGID: 1:317/3 64129b7b   
   PID: hpt/lnx 1.9.0-cur 2019-01-08   
   TID: hpt/lnx 1.9.0-cur 2019-01-08   
    Memories could be lost if two key brain regions fail to sync together,   
   study finds    
      
     Date:   
         March 15, 2023   
     Source:   
         University of Bristol   
     Summary:   
         Learning, remembering something, and recalling memories is supported   
         by multiple separate groups of neurons connected inside and across   
         key regions in the brain. If these neural assemblies fail to sync   
         together at the right time, the memories are lost, a new study   
         has found.   
      
      
         Facebook Twitter Pinterest LinkedIN Email   
   FULL STORY   
   ==========================================================================   
   Learning, remembering something, and recalling memories is supported   
   by multiple separate groups of neurons connected inside and across key   
   regions in the brain. If these neural assemblies fail to sync together at   
   the right time, the memories are lost, a new study led by the universities   
   of Bristol and Heidelberg has found.   
      
      
   ==========================================================================   
   How do you keep track of what to do next? What happens in the brain when   
   your mind goes blank? Short-term memory relies on two key brain regions:   
   the hippocampus and the prefrontal cortex. The researchers set out to   
   establish how these brain regions interact with one another as memories   
   are formed, maintained and recalled at the level of specific groups   
   of neurons. The study, published in Currently Biology, also wanted to   
   understand why memory sometimes fails.   
      
   "Neural assemblies" -- groups of neurons that join forces to process   
   information -- were first proposed over 70 years ago, but have proved   
   difficult to pinpoint.   
      
   Using brain recordings in rats, the research team has shown that memory   
   encoding, storage and recall is supported by dynamic interactions   
   incorporating multiple neural assemblies formed within and between   
   the hippocampus and prefrontal cortex. When the coordination of these   
   assemblies fails, the animals made mistakes.   
      
   Dr Michał Kucewicz, Assistant Professor of Neurology at Gdansk   
   University of Technology, formerly a PhD student at the University of   
   Bristol, and lead author, said: "Our results make potential therapeutic   
   interventions for memory restoration more challenging to target in space   
   and time. On the other hand, our findings have identified critical   
   processes that determine a success or failure in remembering. These   
   present viable targets for therapeutic interventions on the level of   
   neural assembly interactions."  Matt Jones, Professor of Neuroscience   
   in the School of Physiology, Pharmacology and Neuroscience and Bristol   
   Neuroscience and senior author of the paper, added: "Our findings add   
   to evidence that the neural substrates of memory are more distributed in   
   anatomical space and dynamic across time than previously thought based on   
   the neuropsychological models."  The next steps for the research would be   
   to modulate neural assembly interactions, either using drugs or via brain   
   stimulation, which Dr Kucewicz is currently doing in human patients,   
   to test whether disrupting or augmenting them would impair or enhance   
   remembering. The research team presumes the same mechanisms would work   
   in human patients to restore memory functions impaired in a particular   
   brain disorder.   
      
       * RELATED_TOPICS   
             o Health_&_Medicine   
                   # Nervous_System # Psychology_Research # Brain_Tumor #   
                   Birth_Defects   
             o Mind_&_Brain   
                   # Brain-Computer_Interfaces # Memory # Neuroscience #   
                   Brain_Injury   
       * RELATED_TERMS   
             o Neural_network o Computational_neuroscience o Alpha_wave o   
             Memory_bias o Multiple_sclerosis o Neurobiology o Limbic_system   
             o Psychedelic_drug   
      
   ==========================================================================   
   Story Source: Materials provided by University_of_Bristol. Note: Content   
   may be edited for style and length.   
      
      
   ==========================================================================   
   Journal Reference:   
      1. Aleksander P.F. Domanski, Michal T. Kucewicz, Eleonora Russo,   
      Mark D.   
      
         Tricklebank, Emma S.J. Robinson, Daniel Durstewitz, Matt W. Jones.   
      
         Distinct hippocampal-prefrontal neural assemblies coordinate   
         memory encoding, maintenance, and recall. Current Biology, 2023;   
         DOI: 10.1016/ j.cub.2023.02.029   
   ==========================================================================   
      
   Link to news story:   
   https://www.sciencedaily.com/releases/2023/03/230315132454.htm   
      
   --- up 1 year, 2 weeks, 2 days, 10 hours, 50 minutes   
    * Origin: -=> Castle Rock BBS <=- Now Husky HPT Powered! (1:317/3)   
   SEEN-BY: 15/0 106/201 114/705 123/120 153/7715 226/30 227/114 229/110   
   SEEN-BY: 229/111 112 113 307 317 400 426 428 470 664 700 292/854 298/25   
   SEEN-BY: 305/3 317/3 320/219 396/45   
   PATH: 317/3 229/426