MSGID: 1:317/3 640ff864   
   PID: hpt/lnx 1.9.0-cur 2019-01-08   
   TID: hpt/lnx 1.9.0-cur 2019-01-08   
    Attracting stem cells and facilitating bone regeneration by adhesive   
   protein    
      
     Date:   
         March 13, 2023   
     Source:   
         Pohang University of Science & Technology (POSTECH)   
     Summary:   
         Scientists have developed an osteogenic barrier coating material   
         that maximizes the effect of guided bone regeneration (GBR) for   
         implant placements.   
      
      
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   FULL STORY   
   ==========================================================================   
   One of the key factors of success in a dental implant is the condition   
   of the periodontium around the implant. A higher long-term success rate   
   of dental implants requires sufficient and healthy alveolar bone. In   
   those cases where lack of alveolar bone renders setting an implant   
   difficult, the bone should be regenerated sufficiently to receive the   
   implant, whether before or during the implant surgery. Development of   
   osteogenic barrier coating material for implants by a Korean research   
   team is expected to improve the success rate of alveolar bone grafting.   
      
      
   ==========================================================================   
   Three research teams led by Professor Hyung Joon Cha of the Chemical   
   Engineering Department at Pohang University of Science and Technology   
   (POSTECH), Professor Yun Kee Jo of the School of Convergence at Kyungpook   
   National University (KNU), and Professor Sang Ho Jun of the Department of   
   Oral and Maxillofacial Surgery at Korea University Anam Hospital together   
   developed an osteogenic barrier coating material for dental implants that   
   prevents the invasion of soft tissue cells, attracts osteo-progenitor   
   cells including bone stem cells, and sustainably releases the loaded   
   bone morphogenetic protein-2 (BMP-2), significantly facilitating bone   
   regeneration.   
      
   GBR is widely used in dental implant placement. It maintains the space   
   for bones to grow and prevents cells other than osteogenic cells, such   
   as fibroblasts, from populating the bone defect sites, allowing the   
   bone to grow without interference by non-osteogenic cells. However, the   
   GBR approach is still less likely to be successful and requires longer   
   treatment time for those patients with insufficient bone quantity and   
   quality. Depending on the configurations of defect sites, preventing the   
   invasion of the non-osteogenic cells by using barrier membranes alone   
   is not enough to significantly facilitate the bone regeneration.   
      
   The joint research team first loaded BMP-2 on top of the bioengineered   
   material where RGD peptide, cell recognitive motif that is capable   
   of attracting cells, is fused with mussel adhesive protein (MAP) that   
   maintains strong adhesiveness in a wet environment. The team then coated   
   the titanium mesh (Ti-mesh) membrane with it. According to the research   
   findings, the coated barrier membrane exhibited cell occlusivity where   
   fibroblasts could not permeate the membrane.   
      
   The team also found that it induced a high level of bone differentiation   
   in a short period of time inside the membrane by means of high growth   
   of mesenchymal stem cells and release of BMP-2.   
      
   Application of the developed MAP-based barrier coating for guided bone   
   regeneration to a titanium membrane in a rat calvarial defect model showed   
   that the coating roughly doubled the speed of bone tissue regeneration.   
      
   Professor Hyung Joon Cha who led the research said, "This research   
   was conducted based on long-term research cooperation of the joint   
   research team in the area of bone regeneration for implant placement. Its   
   findings revealed the possibility of improving the success rate of implant   
   treatment regardless of the bone condition." He added that the research   
   findings could also be applied to regenerate a variety of hard tissues.   
      
   The research findings were published in the online edition of the   
   Bioengineering & Translational Medicine, a distinguished journal in   
   the field of bioengineering and regenerative medicine. The study was   
   conducted as a part of the Dentistry Technology R&D Project under the   
   Korea Health Technology R&D Project funded by the Ministry of Health &   
   Welfare, the High Value-added Food Technology Development Program funded   
   by the Ministry of Agriculture, Food & Rural Affairs, and the BK21 Four   
   Program by the National Research Foundation of Korea.   
      
       * RELATED_TOPICS   
             o Health_&_Medicine   
                   # Osteoporosis # Bone_and_Spine # Stem_Cells # Leukemia   
             o Matter_&_Energy   
                   # Biochemistry # Organic_Chemistry # Medical_Technology   
                   # Engineering   
       * RELATED_TERMS   
             o Bone_scan o Bone_marrow o Photoelectric_effect o Osteoporosis   
             o Triboelectric_effect o Peripheral_nervous_system o   
             Bone_fracture o Breast_implant   
      
   ==========================================================================   
   Story Source: Materials provided by   
   Pohang_University_of_Science_&_Technology_(POSTECH).   
      
   Note: Content may be edited for style and length.   
      
      
   ==========================================================================   
   Journal Reference:   
      1. Yun Kee Jo, Bong‐Hyuk Choi, Cong Zhou, Sang Ho Jun, Hyung   
      Joon Cha.   
      
         Cell recognitive bioadhesive‐based osteogenic barrier coating   
         with localized delivery of bone morphogenetic protein‐2 for   
         accelerated guided bone regeneration. Bioengineering & Translational   
         Medicine, 2023; DOI: 10.1002/btm2.10493   
   ==========================================================================   
      
   Link to news story:   
   https://www.sciencedaily.com/releases/2023/03/230313215106.htm   
      
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