MSGID: 1:317/3 640177ec   
   PID: hpt/lnx 1.9.0-cur 2019-01-08   
   TID: hpt/lnx 1.9.0-cur 2019-01-08   
    Youth overweight a risk factor for blood clots as adult    
      
     Date:   
         March 2, 2023   
     Source:   
         University of Gothenburg   
     Summary:   
         Being overweight in childhood and in early adulthood are discrete   
         risk factors for blood clots later in life, a University of   
         Gothenburg study shows. The study is based on the early BMI history   
         of more than 37,000 men and information about their thrombi,   
         if any, in adulthood.   
      
      
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   FULL STORY   
   ==========================================================================   
   Being overweight in childhood and in early adulthood are discrete risk   
   factors for blood clots later in life, a University of Gothenburg study   
   shows. The study is based on the early BMI history of more than 37,000   
   men and information about their thrombi, if any, in adulthood.   
      
      
   ==========================================================================   
   The association between obesity and blood clots is already established.   
      
   However, to date it has been unclear how much influence a raised BMI in   
   childhood and puberty exerts. The purpose of the study was to clarify   
   the links between BMI in early life and subsequent thrombi.   
      
   Thrombi usually arise in the legs, often starting in a blood vessel in   
   the calf. Swelling, pain and redness are common symptoms. Treated early,   
   clots are seldom dangerous. However, if one breaks loose, is borne to   
   the lungs in the bloodstream, and adheres to the vessel wall there,   
   the resulting "pulmonary embolism" may be life-threatening.   
      
   The present study comprises 37,672 men in Sweden, born between 1945   
   and 1961.   
      
   It is based on information about height, weight, and BMI from the men's   
   records, first from school health care services (at the age of 8 years)   
   and, second, from medical examinations on enrollment in the Armed Services   
   (at age 20), along with register data on any blood clots up to age 62   
   on average.   
      
   Distinctly elevated thrombus risk It emerges from the results, now   
   published in the Journal of Internal Medicine, that BMI at both ages   
   8 and 20, independently of each other, can be linked to venous blood   
   clots. These may occur in, for example, the leg (deep vein thrombosis,   
   DVT) or the lung (pulmonary embolism).   
      
   In adulthood, two groups were found to be at a significantly increased   
   risk of venous thrombi. The first was individuals who had been overweight   
   both as children and as young adults, while the second was composed of   
   those whose weight in childhood was normal and who became overweight   
   only in early adulthood.   
      
   Moreover, being overweight in both childhood and young adulthood was found   
   to raise the risk of arterial thrombi -- that is, clots resulting from   
   constricted blood vessels with fatty deposits and inflammation. Since   
   there were few cases of arterial blood clots in the study, however,   
   further studies are needed to confirm these findings. All comparisons   
   in the study were made with the control group, whose weight was normal   
   at both 8 and 20 years of age.   
      
   Overweight in puberty an important factor The first and corresponding   
   author of the study is Lina Lilja, a doctoral student at Sahlgrenska   
   Academy, University of Gothenburg, and pediatrician. At the time of the   
   study, she worked at the Kungsho"jd pediatric clinic in Gothenburg. Today,   
   she is a senior physician in child health care in Region Va"stra   
   Go"taland.   
      
   "Our study shows that both overweight in childhood and overweight in young   
   adulthood increase the risk of venous blood clots later in life. The   
   latter, overweight when the men were young adults, proved to be a more   
   influential factor than overweight when they were children," Lilja notes.   
      
   Professor and senior physician Claes Ohlsson and associate professor   
   and senior physician Jenny Kindblom, both of Sahlgrenska Academy at the   
   University of Gothenburg and Sahlgrenska University Hospital, were senior   
   authors of the study.   
      
   "Obesity and overweight during puberty seem to have a marked impact on   
   a person's future risks of venous thrombi," Kindblom concludes.   
      
   The study includes data from the BMI Epidemiology Study (BEST) in   
   Gothenburg, a population study, and from Swedish national registers.   
      
       * RELATED_TOPICS   
             o Health_&_Medicine   
                   # Blood_Clots # Obesity # Diet_and_Weight_Loss #   
                   Hypertension # Healthy_Aging # Heart_Disease #   
                   Children's_Health # Anemia   
       * RELATED_TERMS   
             o Adolescence o Malignant_melanoma   
             o Fertility o Personalized_medicine o   
             Erikson's_stages_of_psychosocial_development o Obesity o   
             Chemical_synapse o Decade_Volcanoes   
      
   ==========================================================================   
   Story Source: Materials provided by University_of_Gothenburg. Note:   
   Content may be edited for style and length.   
      
      
   ==========================================================================   
   Journal Reference:   
      1. Lina Lilja, Maria Bygdell, Jari Martikainen, Annika Rosengren,   
      Jenny M.   
      
         Kindblom, Claes Ohlsson. Overweight in childhood and young adulthood   
         increases the risk for adult thromboembolic events. Journal of   
         Internal Medicine, 2023; DOI: 10.1111/joim.13617   
   ==========================================================================   
      
   Link to news story:   
   https://www.sciencedaily.com/releases/2023/03/230302093408.htm   
      
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