MSGID: 1:317/3 63eb0e74   
   PID: hpt/lnx 1.9.0-cur 2019-01-08   
   TID: hpt/lnx 1.9.0-cur 2019-01-08   
    Time of day may determine the amount of fat burned by exercise    
      
     Date:   
         February 13, 2023   
     Source:   
         Karolinska Institutet   
     Summary:   
         Physical activity at the right time of the day seems able to   
         increase fat metabolism, at least in mice. A new study shows that   
         mice that did exercise in an early active phase, which corresponds   
         to morning exercise in humans, increased their metabolism more   
         than mice that did exercise at a time when they usually rest.   
      
      
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   FULL STORY   
   ==========================================================================   
   Physical activity at the right time of the day seems able to increase   
   fat metabolism, at least in mice. A new study from Karolinska Institutet   
   in Sweden and the University of Copenhagen in Denmark shows that mice   
   that did exercise in an early active phase, which corresponds to morning   
   exercise in humans, increased their metabolism more than mice that did   
   exercise at a time when they usually rest. The results are published in   
   the journal PNAS.   
      
      
   ==========================================================================   
   Physical activity at different times of the day can affect the body in   
   different ways since the biological processes depend on the circadian   
   rhythms of the cells. To ascertain how the time of day at which exercise   
   is done affects the burning of fat, researchers at Karolinska Institutet   
   and the University of Copenhagen studied the adipose tissue of mice after   
   a session of high-intensity exercise performed at two points of the daily   
   cycle, an early active phase and early rest phase (corresponding to a   
   late morning and late evening session, respectively, in humans). The   
   researchers studied various markers for fat metabolism and analysed   
   which genes were active in adipose tissue after exercise.   
      
   Independent of food intake The researchers found that physical activity   
   at an early active phase increased the expression of genes involved   
   in the breakdown of adipose tissue, thermogenesis (heat production)   
   and mitochondria in the adipose tissue, indicating a higher metabolic   
   rate. These effects were observed only in mice that exercised in the   
   early active phase and were independent of food intake.   
      
   "Our results suggest that late morning exercise could be more effective   
   than late evening exercise in terms of boosting the metabolism and the   
   burning of fat, and if this is the case, they could prove of value to   
   people who are overweight," says Professor Juleen R. Zierath from the   
   Department of Molecular Medicine and Surgery and the Department of   
   Physiology and Pharmacology, Karolinska Institutet.   
      
   Improve the health benefits of exercise Mice and humans share many basic   
   physiological functions, and mice are a well- established model for human   
   physiology and metabolism. However, there are also important differences,   
   such as the fact that mice are nocturnal.   
      
   "The right timing seems to be important to the body's energy balance and   
   to improving the health benefits of exercise, but more studies are needed   
   to draw any reliable conclusions about the relevance of our findings to   
   humans," says Professor Zierath.   
      
   The study was conducted in close collaboration with the Novo Nordisk   
   Foundation Center for Basic Metabolic Research (CBMR) at the University   
   of Copenhagen and was financed by the Novo Nordisk Foundation, Novo   
   Nordisk, the Swedish Diabetes Foundation, the Swedish Research Council   
   and Karolinska Institutet.   
      
       * RELATED_TOPICS   
             o Health_&_Medicine   
                   # Fitness # Obesity # Diet_and_Weight_Loss #   
                   Staying_Healthy # Men's_Health # Triglycerides #   
                   Medical_Topics # Nutrition   
       * RELATED_TERMS   
             o Aerobic_exercise o Anaerobic_exercise o House_mouse o   
             Physical_exercise o Swimming o Mouse o Health_benefits_of_tea   
             o Running   
      
   ==========================================================================   
   Story Source: Materials provided by Karolinska_Institutet. Note: Content   
   may be edited for style and length.   
      
      
   ==========================================================================   
   Journal Reference:   
      1. Logan A. Pendergrast, Leonidas S. Lundell, Amy M. Ehrlich,   
      Stephen P.   
      
         Ashcroft, Milena Scho"nke, Astrid L. Basse, Anna Krook,   
         Jonas T. Treebak, Lucile Dollet, Juleen R. Zierath. Time   
         of day determines postexercise metabolism in mouse adipose   
         tissue. Proceedings of the National Academy of Sciences, 2023;   
         120 (8) DOI: 10.1073/pnas.2218510120   
   ==========================================================================   
      
   Link to news story:   
   https://www.sciencedaily.com/releases/2023/02/230213201040.htm   
      
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