MSGID: 1:317/3 63e5c869   
   PID: hpt/lnx 1.9.0-cur 2019-01-08   
   TID: hpt/lnx 1.9.0-cur 2019-01-08   
    Calorie restriction slows pace of aging in healthy adults    
      
     Date:   
         February 9, 2023   
     Source:   
         Columbia University's Mailman School of Public Health   
     Summary:   
         In a first of its kind randomized controlled trial an international   
         team of researchers shows that caloric restriction can slow the pace   
         of aging in healthy adults. The CALERIE[TM] intervention slowed   
         pace of aging measured from participants' blood DNA methylation   
         using the algorithm DunedinPACE (Pace of Aging, Computed from the   
         Epigenome). The intervention effect on DunedinPACE represented a   
         2-3 percent slowing in the pace of aging, which in other studies   
         translates to a 10-15 percent reduction in mortality risk, an   
         effect similar to a smoking cessation intervention.   
      
      
         Facebook Twitter Pinterest LinkedIN Email   
   FULL STORY   
   ==========================================================================   
   In a first of its kind randomized controlled trial an international   
   team of researchers led by the Butler Columbia Aging Center at the   
   Columbia University Mailman School of Public Health shows that caloric   
   restriction can slow the pace of aging in healthy adults. The CALERIE[TM]   
   intervention slowed pace of aging measured from participants' blood DNA   
   methylation using the algorithm DunedinPACE (Pace of Aging, Computed from   
   the Epigenome). The intervention effect on DunedinPACE represented a 2-3   
   percent slowing in the pace of aging, which in other studies translates   
   to a 10-15 percent reduction in mortality risk, an effect similar to a   
   smoking cessation intervention. The results are published online in the   
   journal Nature Aging.   
      
      
   ==========================================================================   
   "In worms, flies, and mice, calorie restriction can slow biological   
   processes of aging and extend healthy lifespan" says senior author   
   Daniel Belsky, PhD, associate professor of epidemiology at Columbia   
   Mailman School and a scientist with Columbia's Butler Aging Center. "Our   
   study aimed to test if calorie restriction also slows biological aging   
   in humans."  The CALERIE[TM] Phase-2 randomized controlled trial, funded   
   by the US National Institute on Aging, is the first ever investigation   
   of the effects of long-term calorie restriction in healthy, non-obese   
   humans. The trial randomized 220 healthy men and women at three sites   
   in the U. S. to a 25 percent calorie- restriction or normal diet for   
   two years. CALERIE[TM] is an acronym for `Comprehensive Assessment of   
   Long-Term Effects of Reducing Intake of Energy'.   
      
   To measure biological aging in CALERIE Trial participants, Belsky's   
   team analyzed blood samples collected from trial participants   
   at pre-intervention baseline and after 12- and 24-months of   
   follow-up. "Humans live a long time," explained Belsky, "so it isn't   
   practical to follow them until we see differences in aging-related disease   
   or survival. Instead, we rely on biomarkers developed to measure the pace   
   and progress of biological aging over the duration of the study." The team   
   analyzed methylation marks on DNA extracted from white blood cells. DNA   
   methylation marks are chemical tags on the DNA sequence that regulate   
   the expression of genes and are known to change with aging.   
      
   In the primary analysis Belsky and colleagues focused on three   
   measurements of the DNA methylation data, sometimes known as   
   "epigenetic clocks". The first two, the PhenoAge and GrimAge clocks,   
   estimate biological age, or the chronological age at which a person's   
   biology would appear "normal". These measures can be thought of as   
   "odometers" that provide a static measure of how much aging a person has   
   experienced. The third measure studied by the researchers was DunedinPACE,   
   which estimates the pace of aging, or the rate of biological deterioration   
   over time. DunedinPACE can be thought of as a "speedometer".   
      
   "In contrast to the results for DunedinPace, there were no effects   
   of intervention on other epigenetic clocks," noted Calen Ryan, PhD,   
   Research Scientist at Columbia's Butler Aging Center and co-lead author   
   of the study.   
      
   "The difference in results suggests that dynamic `pace of aging' measures   
   like DunedinPACE may be more sensitive to the effects of intervention than   
   measures of static biological age."  Our study found evidence that calorie   
   restriction slowed the pace of aging in humans" Ryan said. "But calorie   
   restriction is probably not for everyone. Our findings are important   
   because they provide evidence from a randomized trial that slowing   
   human aging may be possible. They also give us a sense of the kinds of   
   effects we might look for in trials of interventions that could appeal   
   to more people, like intermittent fasting or time-restricted eating."   
   A follow-up of trial participants is now ongoing to determine if the   
   intervention had long-term effects on healthy aging. In other studies,   
   slower DunedinPACE is associated with reduced risk for heart disease,   
   stroke, disability, and dementia. "Our study of the legacy effects of   
   the CALERIE[TM] intervention will test if the short-term effects observed   
   during the trial translated into longer-term reduction in aging-related   
   chronic diseases or their risk factors," says Sai Krupa Das, a senior   
   scientist and CALERIE investigator who is leading the long-term follow   
   up of CALERIE[TM] participants.   
      
   DunedinPACE was developed by Daniel Belsky and colleagues at Duke   
   University and the University of Otago. To develop DunedinPACE,   
   researchers analyzed data from the Dunedin Longitudinal Study, a landmark   
   birth cohort study of human development and aging that follows 1000   
   individuals born in 1972-73 in Dunedin, New Zealand. Researchers first   
   analyzed the rate of change in 19 biomarkers across 20 years of follow-up   
   to derive a single composite measure of the Pace of Aging. Next, the   
   researchers used machine-learning techniques to distill this 20-year   
   Pace of Aging into a single-time-point DNA methylation blood test.   
      
   The values of the DunedinPACE algorithm correspond to the years of   
   biological aging experienced during a single calendar year, providing   
   a measure of the pace of aging.   
      
   The study was supported by US National Institute on Aging grant   
   R01AG061378 and also utilized resources provided by the CALERIE Research   
   Network (R33AG070455) and the Dunedin Study (R01AG032282). Coauthors   
   received additional support from the American Brain Foundation, and NIH   
   grants P30AG028716, R01AG054840, R33AG070455, CIHR RN439810, R01 AG071717,   
   R03AG071549 U01AG060906.   
      
       * RELATED_TOPICS   
             o Health_&_Medicine   
                   # Healthy_Aging # Chronic_Illness # Menopause #   
                   Epigenetics   
             o Plants_&_Animals   
                   # Epigenetics_Research # Biochemistry_Research # Biology   
                   # Biotechnology   
       * RELATED_TERMS   
             o Calorie_restricted_diet o Jogging o Ultraviolet o   
             Baldness_treatments o Insulin-like_growth_factor o UV_index   
             o Collagen o Plum   
      
   ==========================================================================   
   Story Source: Materials provided by   
   Columbia_University's_Mailman_School_of_Public_Health.   
      
   Note: Content may be edited for style and length.   
      
      
   ==========================================================================   
   Journal Reference:   
      1. R Waziry, DL Corcoran, KM Huffman, MS Kobor, M Kothari, VB Kraus, WE   
         Kraus, DTS Lin, CF Pieper, ME Ramaker, M Bhapkar, SK Das, L   
         Ferrucci, WJ Hastings, M Kebbe, DC Parker, SB Racette, I Shalev,   
         B Schilling, DW Belsky. Effect of long-term caloric restriction   
         on DNA methylation measures of biological aging in healthy adults   
         from the CALERIE trial.   
      
         Nature Aging (in press), 2023 DOI: 10.1101/2021.09.21.21263912   
   ==========================================================================   
      
   Link to news story:   
   https://www.sciencedaily.com/releases/2023/02/230209114738.htm   
      
   --- up 49 weeks, 3 days, 10 hours, 50 minutes   
    * Origin: -=> Castle Rock BBS <=- Now Husky HPT Powered! (1:317/3)   
   SEEN-BY: 15/0 106/201 114/705 123/120 153/7715 226/30 227/114 229/110   
   SEEN-BY: 229/111 112 113 114 307 317 400 426 428 470 664 700 292/854   
   SEEN-BY: 298/25 305/3 317/3 320/219 396/45   
   PATH: 317/3 229/426