MSGID: 1:317/3 6274a4c1   
   PID: hpt/lnx 1.9.0-cur 2019-01-08   
   TID: hpt/lnx 1.9.0-cur 2019-01-08   
    Combining certain meds with ibuprofen can permanently injure kidneys   
    Commonly prescribed hypertension drugs may be harmful in combination with   
   ibuprofen    
      
     Date:   
         May 5, 2022   
     Source:   
         University of Waterloo   
     Summary:   
         Anyone who is taking a diuretic and a renin-angiotensin system   
         (RSA) inhibitor for high blood pressure should be cautious about   
         also taking ibuprofen, according to new research.   
      
      
      
   FULL STORY   
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   Anyone who is taking a diuretic and a renin-angiotensin system (RSA)   
   inhibitor for high blood pressure should be cautious about also taking   
   ibuprofen, according to new research.   
      
      
   ==========================================================================   
   Diuretics and RSA inhibitors are commonly prescribed together for people   
   with hypertension and are available under various pharmaceutical brand   
   names.   
      
   Painkillers such as ibuprofen are available over-the-counter in most   
   pharmacies and stores in popular brands.   
      
   Researchers at the University of Waterloo used computer-simulated drug   
   trials to model the interactions of the three drugs and the impact on   
   the kidney. They found that in people with certain medical profiles,   
   the combination can cause acute kidney injury, which in some cases can   
   be permanent.   
      
   "It's not that everyone who happens to take this combination of drugs   
   is going to have problems," said Anita Layton, professor of applied   
   mathematics at Waterloo and Canada 150 Research Chair in mathematical   
   biology and medicine.   
      
   "But the research shows it's enough of a problem that you should exercise   
   caution."  Computer-simulated drug trials can quickly produce results   
   that would take much longer in human clinical trials. Layton and her   
   team use mathematics and computer science to give medical practitioners   
   a head start with issues like drug complications.   
      
   The research, in this case, can also speak directly to the many people   
   who are taking drugs for hypertension and may reach for a painkiller   
   with ibuprofen without giving it much thought.   
      
   "Diuretics are a family of drugs that make the body hold less water,"   
   Layton said. "Being dehydrated is a major factor in acute kidney injury,   
   and then the RAS inhibitor and ibuprofen hit the kidney with this triple   
   whammy. If you happen to be on these hypertension drugs and need a   
   painkiller, consider acetaminophen instead."  Layton's new research   
   paper, with co-authors Jessica Leete, Carolyn Wang, and Francisco   
   J. Lo'pez-Herna'ndez, "Determining risk factors for triple whammy acute   
   kidney injury," appears in the journal Mathematical Biosciences.   
      
      
   ==========================================================================   
   Story Source: Materials provided by University_of_Waterloo. Note:   
   Content may be edited for style and length.   
      
      
   ==========================================================================   
   Journal Reference:   
      1. Jessica Leete, Carolyn Wang, Francisco J. Lo'pez-Herna'ndez,   
      Anita T.   
      
         Layton. Determining risk factors for triple whammy acute kidney   
         injury.   
      
         Mathematical Biosciences, 2022; 347: 108809 DOI: 10.1016/   
         j.mbs.2022.108809   
   ==========================================================================   
      
   Link to news story:   
   https://www.sciencedaily.com/releases/2022/05/220505085618.htm   
      
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