MSGID: 1:317/3 6274a49d   
   PID: hpt/lnx 1.9.0-cur 2019-01-08   
   TID: hpt/lnx 1.9.0-cur 2019-01-08   
    'Smart' diaper for bedside urine testing    
      
     Date:   
         May 5, 2022   
     Source:   
         American Chemical Society   
     Summary:   
         Urine can reveal a lot about a person's health. But physicians   
         don't currently have a convenient or fast way of tracking   
         the concentration of important compounds in their patients'   
         urine. Now, researchers have designed a flexible sensor that fits   
         in a diaper, measures multiple components in urine and can share   
         those results over Bluetooth to provide real-time bedside analyses   
         for incontinent, elderly or infant patients.   
      
      
      
   FULL STORY   
   ==========================================================================   
   Urine can reveal a lot about a person's health. But physicians don't   
   currently have a convenient or fast way of tracking the concentration of   
   important compounds in their patients' urine. Now, researchers reporting   
   in ACS Applied Nano Materials have designed a flexible sensor that   
   fits in a diaper, measures multiple components in urine and can share   
   those results over Bluetooth to provide real-time bedside analyses for   
   incontinent, elderly or infant patients.   
      
      
   ==========================================================================   
   The concentration of certain compounds in urine can provide information   
   about many different conditions, including kidney disease, urinary   
   tract infections and electrolyte deficiencies. Though many people with   
   diabetes monitor their glucose levels with blood tests, glucose levels in   
   their urine can also reveal spikes or dips. To analyze urine, however,   
   physicians typically must order a urinalysis from a hospital lab, which   
   takes time, or use paper test strips, which aren't very sensitive. Neither   
   system can deliver fast, bedside analyses.   
      
   Some researchers have explored wearable devices to monitor health markers   
   - - like electrolyte and sugar content in sweat. So, Xi Xie, Hui-Jiun Chen   
   and colleagues wanted to design a similar type of wearable device that   
   could accurately and sensitively measure the concentration of multiple   
   health markers in urine and give real-time feedback to care providers.   
      
   The team first fabricated a flexible electrode array about the size of   
   a U.S.   
      
   quarter. They included five different electrodes on the array that   
   were designed to specifically detect potassium ions, sodium ions,   
   hydrogen peroxide, uric acid or glucose, which are biomarkers for various   
   conditions. Then they connected the array to a circuit board that had a   
   Bluetooth module and lithium- ion battery power source. When the array   
   was exposed to urine samples from three volunteers, it performed as well   
   as a commercial urine test system. Next, the researchers incorporated the   
   array into a diaper and found that, when urine was present, they could   
   get readable signals for the biomarkers. However, they anticipate that   
   in a real-world setting, where dry diapers become slowly saturated with   
   urine, the electrode array would have to take multiple measurements to   
   get stable readings. So, with optimization, this "smart" diaper could   
   be a way to provide quick and painless urinalysis with wearable device   
   technology, the researchers say.   
      
   The authors acknowledge funding from the National Key R&D Program of   
   China; the National Natural Science Foundation of China; the China   
   Postdoctoral Science Foundation; the Science and Technology Program   
   of Guangzhou, China; the Guangdong Basic and Applied Basic Research   
   Foundation; the Key Program of Sun Yat-Sen University; and the Pazhou   
   Lab, Guangdong.   
      
      
   ==========================================================================   
   Story Source: Materials provided by American_Chemical_Society. Note:   
   Content may be edited for style and length.   
      
      
   ==========================================================================   
   Journal Reference:   
      1. Xiangling Li, Changyuan Zhan, Qiqi Huang, Mengyi He, Cheng Yang,   
         Chengduan Yang, Xinshuo Huang, Meiwan Chen, Xi Xie, Hui-Jiuan   
         Chen. Smart Diaper Based on Integrated Multiplex Carbon   
         Nanotube-Coated Electrode Array Sensors for In Situ Urine   
         Monitoring. ACS Applied Nano Materials, 2022; 5 (4): 4767 DOI:   
         10.1021/acsanm.1c04220   
   ==========================================================================   
      
   Link to news story:   
   https://www.sciencedaily.com/releases/2022/05/220505114638.htm   
      
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