MSGID: 1:317/3 62735345   
   PID: hpt/lnx 1.9.0-cur 2019-01-08   
   TID: hpt/lnx 1.9.0-cur 2019-01-08   
    New study reviews anti-cancer activity of sustained release capsaicin   
   formulations    
      
     Date:   
         May 4, 2022   
     Source:   
         Marshall University Joan C. Edwards School of Medicine   
     Summary:   
         A study provides the first published in-depth description   
         of the anti- cancer activity of capsaicin sustained release   
         formulations. Capsaicin is naturally found in chili peppers and   
         is the agent that provides the hot and spicy taste when eating   
         chili peppers.   
      
      
      
   FULL STORY   
   ==========================================================================   
   A study by a team of researchers at the Marshall University Joan   
   C. Edwards School of Medicine provides the first published in-depth   
   description of the anti-cancer activity of capsaicin sustained release   
   formulations. Capsaicin is naturally found in chili peppers and is   
   the agent that provides the hot and spicy taste when eating chili   
   peppers. Sustained release formulation of capsaicin are being explored   
   for extended anti-cancer activity.   
      
      
   ==========================================================================   
   Recently published in Pharmacology & Therapeutics, a leading medical   
   review journal in the field of pharmacology, the article chronicles   
   the growth- suppressive activity of sustained release capsaicin drugs,   
   including solid dispersion systems, liposomes, phospholipid complexes   
   and nanoparticles. This is the first publication to provide an in-depth   
   description of the anti-cancer activity of capsaicin sustained release   
   formulations. The research team was led by Associate Professor of   
   Biomedical Sciences Piyali Dasgupta, Ph.D., and Professor of Biomedical   
   Sciences Monica Valentovic, Ph.D.   
      
   "This review article is the first to provide a comprehensive overview of   
   capsaicin formulations in human cancer," said Dasgupta, corresponding   
   author on the publication. "Previous publications in the literature   
   only briefly address sustained release formulations of capsaicin."   
   The nutritional agent capsaicin displayed robust growth-inhibitory   
   activity in a diverse array of human cancers. However, the clinical   
   applications of capsaicin as a viable anti-cancer agent were hindered   
   by three factors -- poor solubility, low bioavailability and spicy flavor.   
      
   "Oral use of capsaicin is associated with unfavorable side effects   
   such as stomach cramps, nausea, a burning sensation in the gut and   
   gastrointestinal irritation," said Valentovic, a senior author on the   
   publication. "A strategy to overcome these drawbacks is the development of   
   different delivery systems, such as encapsulating capsaicin in long-acting   
   sustained release drug delivery systems could allow for more consistent   
   capsaicin levels that could be more efficient as anti-cancer agents."   
   In addition to Dasgupta and Valentovic, clinical faculty Maria T. Tirona,   
   M.D., Joshua Hess, M.D., and Paul Finch, M.D., contributed to the   
   publication as well as co-authors Stephen Richbart, Justin Merritt,   
   Ashley Cox, Emily Moles and Katie Brown.   
      
   This research was supported by the R15 Academic Research Enhancement   
   Award Grants from the National Institutes of Health (1R15CA161491-01A1,   
   2R15CA161491- 02, 2R15CA161491-03, R15AI151970-01 and1R15HL145573-01), the   
   West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE)   
   grant (P20GM103434) as well as the National Science Foundation (SURE)   
   and West Virginia NASA State Grant Consortium.   
      
      
   ==========================================================================   
   Story Source: Materials provided by   
   Marshall_University_Joan_C._Edwards_School_of_Medicine.   
      
   Note: Content may be edited for style and length.   
      
      
   ==========================================================================   
   Journal Reference:   
      1. Justin C. Merritt, Stephen D. Richbart, Emily G. Moles, Ashley   
      J. Cox,   
         Kathleen C. Brown, Sarah L. Miles, Paul T. Finch, Joshua   
         A. Hess, Maria T. Tirona, Monica A. Valentovic, Piyali   
         Dasgupta. Anti-cancer activity of sustained release capsaicin   
         formulations. Pharmacology & Therapeutics, 2022; 238: 108177 DOI:   
         10.1016/j.pharmthera.2022.108177   
   ==========================================================================   
      
   Link to news story:   
   https://www.sciencedaily.com/releases/2022/05/220504135629.htm   
      
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