MSGID: 1:317/3 627201cf   
   PID: hpt/lnx 1.9.0-cur 2019-01-08   
   TID: hpt/lnx 1.9.0-cur 2019-01-08   
    Diet type can increase potentially harmful gas in the gut    
      
     Date:   
         May 3, 2022   
     Source:   
         University of Minnesota Medical School   
     Summary:   
         Scientists looked at colonic hydrogen sulfide -- a toxic gas in   
         the body that smells like rotten eggs -- production in people in   
         response to animal- and plant-based diet interventions.   
      
      
      
   FULL STORY   
   ==========================================================================   
   Published in Clinical Nutrition, researchers from the University of   
   Minnesota Medical School looked at colonic hydrogen sulfide -- a toxic   
   gas in the body that smells like rotten eggs -- production in people in   
   response to animal- and plant-based diet interventions.   
      
      
   ==========================================================================   
   "Although the role of hydrogen sulfide has long been a subject of great   
   interest in the pathogenesis of multiple important diseases -- such as   
   ulcerative colitis, colon cancer, and obesity -- past investigations   
   have not been able to link dietary data, microbiome characterization   
   and actual hydrogen sulfide production," said Alexander Khoruts,   
   MD, a gastroenterologist in the U of M Medical School and M Health   
   Fairview. "This is what we have done here."  From a human cohort, the   
   study supports the general hypothesis that hydrogen sulfide produced by   
   the gut microbiota increases with an animal-based diet.   
      
   However, the results also suggested the existence of gut microbiome   
   enterotypes that respond differentially and even paradoxically to   
   different dietary input.   
      
   The study found that:   
       * In the majority of participants, a plant-based diet resulted in   
       a lower   
         hydrogen sulfide production compared to an animal-based (i.e.,   
         western) diet.   
      
       * As expected, a plant-based diet contained more fiber, while   
       an animal-   
         based diet contained more protein.   
      
       * In some individuals, plant-based diets did not lower hydrogen   
       sulfide   
         production and even led to some increases in it.   
      
       * Preliminary results suggested the existence of different   
       compositions of   
         gut microbiota (enterotypes) that correlate with differential   
         responsiveness to diet in terms of hydrogen sulfide production.   
      
   "The study was consistent with the general understanding that regular   
   intake of fiber-containing foods is beneficial to gut health,"   
   said Dr. Levi Teigen, a nutrition researcher in the Division of   
   Gastroenterology in the U of M Medical School. "Future analyses of   
   the gut microbiome may help to individualize nutrition interventions."   
   The study was funded by Healthy Foods Healthy Lives, Achieving Cures   
   Together, the Allen Foundation and the University of Minnesota MnDRIVE   
   Initiative. The research team envisions future work that will lead   
   to more personalized nutritional counseling that will be informed by   
   microbiome-based diagnostics.   
      
      
   ==========================================================================   
   Story Source: Materials provided by   
   University_of_Minnesota_Medical_School. Original written by Kat   
   Dodge. Note: Content may be edited for style and length.   
      
      
   ==========================================================================   
   Journal Reference:   
      1. Levi Teigen, Prince P. Mathai, Sharon Lopez, Michael Matson,   
      Baila Elkin,   
         Daria Kozysa, Amanda J. Kabage, Matthew Hamilton, Byron P. Vaughn,   
         Michael J. Sadowsky, Alexander Khoruts. Differential hydrogen   
         sulfide production by a human cohort in response to animal- and   
         plant-based diet interventions. Clinical Nutrition, 2022; 41 (6):   
         1153 DOI: 10.1016/ j.clnu.2022.03.028   
   ==========================================================================   
      
   Link to news story:   
   https://www.sciencedaily.com/releases/2022/05/220503190209.htm   
      
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